Keynote/Invited
Speakers
Dr. Daniel Schmoldt
National Program Leader Instrumentation and Sensors
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Title: The Interplay of Biology and Engineering for Smarter
Applications”
Dr. Daniel Schmoldt is the National Program
Leader for instrumentation and sensors in Cooperative State Research, Education
& Extension Service (CSREES) of United State Department of Agriculture
(USDA). He provides national leadership to develop, coordinate, and manage
research, education and extension programs in the areas of sensors, and
automation in food and agricultural applications. Dan engages land-grant universities, national
laboratories, industrial partners, and other federal agencies to mine sensor
and instrumentation technology advancements along with decision support systems
for processing of agricultural/forest products, precision agriculture/forestry,
and environmental quality; provides leadership to identify and develop those
technologies, wherever they exist, and serves as a liaison between those
organizations and the agricultural/forestry agencies best suited to develop and
demonstrate benefits.
Dr. Bhanu Jena
Ph.D., D.Sc., (dr. h.c. mult.)
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Title: Force Spectroscopy in the Discovery of
a New Cellular Structure –‘the Porosome’ - the
Universal Secretory Machinery in Cells
Abstract: Understanding the molecular mechanism of secretion
and membrane fusion will not only help in the design and development of drugs
to block infections and ameliorate secretory defects,
but will help in the design and development of tailored drug delivery systems
for targeted delivery and sustained release. Studies on the interaction of ions
at the membrane surface, will enable the development
of smart membrane-based bio-sensors. For
example, lipid membrane has been developed for use in sensing glucose, or
toxins such as cholera toxin. These biosensors hold great promise both in
medical applications, and their selectivity and sensitivity in detection of
environmental toxins and biological agents. These developments are expected to
reduce the threat of the use of chemical and biological warfare agents by
terrorist organizations, therefore improving both national security and public
health." Secretion occurs in all living cells and involves the delivery of
intracellular products to the cell exterior. The molecular machinery and
mechanism of cell secretion and membrane fusion have been determined using
force spectroscopy and associated approaches. Secretory
products are packaged and stored in membranous sacs or vesicles within the
cell. When the cell needs to secrete, the secretory
vesicles containing them dock and fuse at plasma membrane-associated supramolecular structures, called porosomes,
to release their contents. Specialized cells for neurotransmission, enzyme
secretion, or hormone release use a highly regulated secretory
process. Similar to other fundamental cellular processes, cell secretion is
precisely regulated. During secretion, swelling of secretory
vesicles results in a build-up of intravesicular
pressure, allowing expulsion of vesicular contents. The extent of vesicle
swelling dictates the amount of vesicular contents expelled. The discovery of
the porosome as the universal secretory
machinery, its isolation, its structure and dynamics at nanometer resolution
and in real time, and its biochemical composition and functional reconstitution
into artificial lipid membrane, have been determined. The molecular mechanism
of secretory vesicle swelling and the fusion of
opposing bilayers, that is, the fusion of secretory vesicle membrane at the base of the porosome membrane, have also been determined. These
findings reveal, for the first time, the universal molecular machinery and
mechanism of cell secretion.
Bhanu Pratap Jena,
Ph.D. (Hon. Doc. Mult.)
Dr. Jena has
a Ph.D. degree in Zoology (Molecular Endocrinology), along with the Research
Excellence Award and the Humanitarian Award, from the President of
Dr. Hongda Chen, Ph.D.
National Program Leader, Bioprocessing
Engineering
USDA/CSREES,
Title: Nanotechnology for Sensors to Enhance Agricultural Biosecurity, Food Safety and Quality.”
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Dr. Hongda Chen is the National Program Leader for
Bioprocess Engineering and Nanotechnology in Cooperative State Research,
Education & Extension Service (CSREES) of United State Department of
Agriculture (USDA). He provides national leadership to develop, coordinate, and
manage research, education and extension programs in the areas of value-added
novel products for food and nonfood applications. He represents USDA in the
National Science and Technology Council (NSTC) subcommittee on Nanoscale Science, Engineering and Technology (NSET). He is
a frequently sought speaker on nanotechnology for agriculture and foods at
professional conferences, symposia, and strategic planning meetings worldwide.
Prof. Norm Scott, Ph.D.
Professor, Biological and environmental Engineering
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Title:
The World of
2100: Nanobiotechnology, Renewable Energy and
Sustainability
Dr. Scott is a professor in the department of Biological and
Environmental Engineering. He has been involved
in bioengineering research and teaching throughout my academic career. Research
has focused on thermoregulation in poultry, biomechanics of machine milking of
dairy cows and electronic applications in agriculture, with particular
attention to automatic identification and estrus detection of livestock. A
principal theme of this research is biothermal
engineering for plants, animals and humans. He has redirected his research and
teaching interests to sustainable development. I believe "sustainable
development" is the dominant economic, environmental and social issue for
the 21st century. He has obtained
numerous awards. He served as the Vice President for Research,
Dr. Chang Liu
Professor, Electrical Engineering
Univeristy of
Title: Micro and Nanotechnology for Biodetection
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Micro
electromechanical systems (MEMS) and nanotechnology promises to provide revoluntionary sensing principles and platforms for biodetection with applications in the agriculture industry.
In this talk, I will discuss microfluid lab on chip
technology developed at the Center for Nano Science and
Technology of the
throughput, low cost, high sensitivity and high selectivity hold great promise for applications in agriculture for crop disease identification and prevention.
Dr. Liu's research
interests cover micro sensors, microfluidic
lab-on-a-chip systems, and applications of MEMS for nanotechnology. He has 13 years of research
experience in the MEMS area and has published 100 technical papers. Prof. Liu
received the NSF CAREER award in 1998 and is currently an Associate Editor of
the IEEE Sensors Journal. He teaches undergraduate and graduate courses
covering the areas of MEMS, solid state electronics, and heat transfer.
He won a campus "Incomplete list of teachers ranked as excellent"
honor in 2001. Prof. Liu is currently a senior member of the IEEE. His work has
been cited in popular media many times. Dr. Liu is a co-founder and a member of
technical advisor board of NanoInk Corporation. He
has consulted for several major MEMS companies. In 2002, he has been elected to
the "Inventor Wall of Fame" by the Office of Technology Management of
the
Dr. Subhas Malghan
Deputy Director, Office of Science and Engineering Laboratories
Center for Devices and Radiological Health/FDA
Title: Science and
Regulatory Issues of Nanotechnology
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Nanotechnology is not a household phrase yet, but an
incredible variety of innovations are beginning to emerge in all fields
including healthcare. There is some talk that nanoscale robots will one
day be swimming in our bloodstreams looking to eradicate cancer. Perhaps
nanotechnology has the potential to lead to such advances; but there are
considerable challenges in science and regulatory aspects. The Center for
Devices and Radiological Health (CDRH), one of the six Centers in the U.S. Food
and Drug Administration, is responsible for review of medical devices. CDRH is a science based center and
science provides the basis for regulatory decisions. That means Center’s work
includes ensuring rapid access to safe and effective medical devices, and
overseeing the safety and quality of medical devices. The Center is continuing
to strengthen the scientific underpinning of regulatory framework that serves
as a bridge to innovation.
The pathway
for regulation of nanotechnology-based medical products is based on past
experiences of dealing with emerging technologies. The Center is proceeding
with the existing battery of regulatory tools. In addition, our focus is on
conducting relevant research to assist Center’s regulatory responsibilities.
These research projects are primarily
addressing measurement methods and mechanistic understanding of nanoparticles (NP) behavior from physical, chemical and
biological aspects.
This talk will provide an overview
of challenges related to the development of nanotechnology applications related
to the science, technology and regulatory aspects.
Dr. Subhas G. Malghan is with the Food and Drug Administration where he
is the Deputy Director in the Office of Science and Engineering Laboratories,
the laboratory arm of the Center for Devices and Radiological Health, Food and
Drug Administration. Dr. Malghan received his doctorate from the University of
California in Materials Science and Engineering, and subsequently held research
and management positions in academic and industrial research organizations. His
research contributions are primarily in colloid science, and particle
technology. His prior work experience involves at NSIT as acting director and
deputy director. At CDRH/FDA, he is responsible for managing and directing a
program on prioritization of laboratory science, the goal of which is to
conduct laboratory research to meet regulatory needs of the Center. In addition,
he coordinates nanotechnology research in the Center as well as serves as a
member of the newly organized FDA nanotechnology taskforce.
Dr.
Department
of Agricultural and
Title: Sensors
needs and issues for environmental/water systems
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Title: Application
of insulator-based polymer micorfluidic devices as particle separator and the
impact of dynamic surface coating on performance.
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Blake Simmons received his Ph.D. in Chemical
Engineering from
Dr. Irfan Ahmad
Associate Director, Center
for Nanoscale Science and Technology;
Co-PI/Project Coordinator
NCI-Siteman
Nanomedicine for Developing Cancer Therapies
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Abstract: The National Cancer
Institute (
Dr. Kenneth Watkin,
Professor, Beckman Institute of Advanced
Science & Technology
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Title: Advances in Screening the Cytotoxic
Properties of Plant Extracts
Rapid and accurate
quantitative screening the cytotoxic properties of plant
extracts upon cells has enormous potential for drug development. In ths presentation we describe a new method for cytotoxic screening that utilizes label-free photonic
crystal optical biosensors incorporated within standard format 96-well microplates is described.
The biosensors and associated imaging detection instrument enable
visualization and quantitative measurement of cell populations attached to the
sensor surface with sensitivity sufficient for the detection of individual
cells without the use of labels or stains that typically result in the death of
the cells under study. The detection
method allows repeated measurement of the same cells without removing them from
their culture environment, and thus allows direct determination of proliferation
and apoptosis rates. In this work, the
biosensor cell assay is used to screen the effect of a 61-member compound
library of plant extracts upon human breast cancer cells, in which some members
of the library are shown to induce apoptosis, while others increase the rate of
cancer cell proliferation. The results
are broadly applicable to a wide range of cell types and compounds, while the
assay is simpler and more rapid than alternative apoptosis/proliferation assays.
Dr. Kenneth L Watkin, Ph.D. (U
Dr. Ravi Pandey
Professor and Department Chair
Department of Physics,
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Title: First principles study of
DNA-wrapped carbon nano-tubes
Prof. Bill Bacthelor,
Ph.D.
Hearin Eminent Professor and Head of Agricultural and Biological
Engineering, Co-Director of the
Title: Integrating Sensor-related courses
in Engineering Curriculum”
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Dr. Batchelor is a Professor and Head of the Agricultural and
Biological Engineering department at Mississippi State University in January of
2005 and was named a Hearin Eminent Professor by the
Bagley College of Engineering at MSU in 2006. He is also Co-Director of the